During the 1st and 2nd centuries AD a port was built on the northern shores of the nearby Bassin de Thau, a large lake connected to the sea. There is evidence of pottery workshops, which made amphorae, jugs used to store wine. It was during this time At this time that Villa Loupian became a substantially sized farmstead with a large vineyard - its storehouse is estimated to have held 1500 hl of wine.

Later, in the 5th century AD, the Villa was greatly expanded, and it became a small mansion. The wealth of the owner can be seen in mosaic floors - each of the 13 rooms on the ground floor were covered in multicoloured and complex mosaics. At this time, the nearby pottery workshops were also producing household pottery.

The mosaic floors at Loupian are quite unique in that they not only display the usual Aquitaine elements common in this area, they also appear to have elements more commonly seen in Syria. A building of 1000m2 has been erected over the remains of the villa to protect these outstanding mosaics.